❞ رسالة Synthesis of 3 substituted 8 hydroxy 3,4 dihydroisocoumarins ❝ ⏤ Naruki Tahara, Tsutomu Fukuda and Masatomo Iwao

Abstract—Sequential treatment of 4,4-dimethyl-2-(o-tolyl)oxazoline in THF with sec-BuLi, aromatic or aliphatic aldehydes, sec-
BuLi, B(OMe)3, and H2O2 produced the laterally alkylated and ortho-hydroxylated oxazolines in one-pot. Treatment of these

products with TFA in aqueous THF provided 3-substituted 8-hydroxy-3,4-dihydroisocoumarins in 44–75% overall yields. This
procedure allowed the short synthesis of (±)-hydrangenol and (±)-phyllodulcin, naturally occurring 3,4-dihydroisocoumarins of
pharmacological interest. A
Naruki Tahara, Tsutomu Fukuda and Masatomo Iwao - ❰ له مجموعة من الإنجازات والمؤلفات أبرزها ❞ Optional ortho and lateral lithiations of4,4dimethyl2(otolyl)oxazolines ❝ ❞ Synthesis of 3 substituted 8 hydroxy 3,4 dihydroisocoumarins ❝ ❱
من رسائل و أبحاث علمية بحته كتب الدراسات العليا - مكتبة الكتب العلمية.