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Plumb's Veterinary Drug Handbook: Desk 7th (seventh) Edition by Plumb, Donald C. [2011] Paperback – 1994
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Now in a fully updated seventh edition, Plumb's Veterinary Drug Handbook remains the most complete source of drug information relevant for animals available. Providing referenced dosing recommendations in each monograph, this book offers doses for a wide range of species, including dogs, cats, exotic animals, and farm animals, in a single resource. The book also includes detail on key aspects for appropriate use of each drug, including pharmacology, pharmacokinetics, contraindications, adverse effects, safety during pregnancy or nursing, overdoses, drug interactions, monitoring, chemistry and stability, storage, compatibility, and available products. The seventh edition adds 22 new drug monographs, as well as updated dosages and information for existing drugs. A noteworthy feature is the Prescriber Highlights section found at the beginning of each monograph that allows readers a quick method of finding important information for that drug.

Non-specific injectable immunostimulant that has been tried in FeLV-, FIV, or FIP-positive cats, & vaccine–induced fibrosarcomas (intralesional)
Use is controversial; little, if any controlled study documentation supporting efficacy in veterinary medicine
Adverse effects include: Possible hypersensitivity reactions, localized necrosis at injection sites; bolus IV administration can cause salivation,
weakness, collapse, tachycardia, tachypnea; intralesional injection can cause prolonged pain at site; intraperitoneal injection can cause monocyte
infiltrates on peritoneal surfaces, liver, & spleen with resultant abdominal pain, diarrhea and vomiting.
Topical products available; potentially can reduce wound healing time

Uses/Indications
Veterinary acemannan injection is labeled for use in dogs or cats as an aid in the treatment (i.e., surgery) and clinical management of fibrosarcoma. It has been tried as
a treatment for FeLV, FIV, and FIP infections in cats, but clinical efficacy has not been adequately proven by controlled clinical studies.
Acemannan has been used in dogs as an intralesional injection for papillomatosis. It reportedly has been used in horses, but no specific information on this was
located.
Pharmacology/Actions
Acemannan’s immunostimulant activity is thought as a result of inducing increases in TNF-alpha, interferon, and IL-1. At injection sites, increased lymphocytic
infiltration and accumulation have been noted. In tissue cultures, acemannan has suppressed HIV replication.
Pharmacokinetics
No information was located.
Contraindications/Precautions/Warnings
The manufacturer lists no contraindications to using acemannan, however, it should not be used in patients who have demonstrated past severe hypersensitivity
reactions to it.
Adverse Effects
While the manufacturer does not list any specific adverse effects associated with use, hypersensitivity or localized injection reactions (e.g., necrosis) are possible.
Hyperactivity, lethargy, fever and hypotension have been reported with systemic use of the drug.
Bolus IV administration can cause salivation, weakness, collapse, hypotension, tachycardia and tachypnea. Intralesional injection can cause bleeding or prolonged

Bolus IV administration can cause salivation, weakness, collapse, hypotension, tachycardia and tachypnea. Intralesional injection can cause bleeding or prolonged
pain at the injection site. Intraperitoneal injection can cause monocyte infiltrates on peritoneal surfaces, lung, liver, and spleen. Abdominal pain, vomiting and diarrhea
have been reported with high dose, intraperitoneal injections.
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